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dc.contributor.authorJones, MJ
dc.contributor.authorJones, MC
dc.date.accessioned2023-12-18T12:44:30Z
dc.date.available2023-12-18T12:44:30Z
dc.date.issued2024-02
dc.identifier.issn0955-0674
dc.identifier.issn1879-0410
dc.identifier.other102288
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/21807
dc.description.abstract

Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not fully understood. The composition and physical properties of the ECM can have profound effects on cell proliferation but can also promote cell cycle exit and quiescence. Furthermore, during tumor development and progression, changes in the ECM can drive both cancer cell proliferation and dormancy. Cell-matrix adhesion is primarily sensed via integrin-associated adhesion complexes, which in turn are regulated by the cell cycle machinery. In particular, cyclin-dependent kinase 1 (CDK1) has been shown to play a crucial role in regulating adhesion complexes during interphase and entry into mitosis. These reciprocal links between cell cycle progression and cell-matrix interactions are now being identified.

dc.format.extent102288-102288
dc.format.mediumPrint-Electronic
dc.languageen
dc.publisherElsevier BV
dc.subjectHumans
dc.subjectCell Cycle
dc.subjectCell Cycle Proteins
dc.subjectCell Cycle Checkpoints
dc.subjectCell Proliferation
dc.subjectCell Adhesion
dc.subjectMitosis
dc.subjectNeoplasms
dc.titleCell cycle control by cell-matrix interactions
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38056140
plymouth.volume86
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.ceb.2023.102288
plymouth.publication-statusPublished
plymouth.journalCurrent Opinion in Cell Biology
dc.identifier.doi10.1016/j.ceb.2023.102288
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|Faculty of Health|Peninsula Medical School
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA|UoA01 Clinical Medicine
dc.publisher.placeEngland
dcterms.dateAccepted2023-11-08
dc.date.updated2023-12-18T12:44:30Z
dc.identifier.eissn1879-0410
dc.rights.embargoperiodforever
rioxxterms.versionofrecord10.1016/j.ceb.2023.102288


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