Show simple item record

dc.contributor.authorDhanda, A
dc.contributor.authorAndrade, J
dc.contributor.authorAllende, H
dc.contributor.authorAllgar, V
dc.contributor.authorBailey, M
dc.contributor.authorCallaghan, L
dc.contributor.authorCocking, L
dc.contributor.authorGoodwin, E
dc.contributor.authorHawton, A
dc.contributor.authorHayward, C
dc.contributor.authorHudson, B
dc.contributor.authorIngram, W
dc.contributor.authorJeffery, A
dc.contributor.authorKing, A
dc.contributor.authorLavers, V
dc.contributor.authorLomax, J
dc.contributor.authorMcCune, CA
dc.contributor.authorMusicha, C
dc.contributor.authorParker, R
dc.contributor.authorRollinson, C
dc.contributor.authorWilks, J
dc.contributor.authorCreanor, ES
dc.date.accessioned2024-02-06T11:08:11Z
dc.date.available2024-02-06T11:08:11Z
dc.date.issued2024-01
dc.identifier.issn2054-4774
dc.identifier.issn2054-4774
dc.identifier.othere001267
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/22031
dc.description.abstract

Objective The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether people with ARLD and AUD admitted to hospital could be recruited to and retained in a trial of Functional Imagery Training (FIT), a psychological therapy that uses mental imagery to reduce alcohol craving. We conducted a multicentre randomised pilot trial of treatment as usual (TAU) versus FIT+TAU in people admitted to hospital with ARLD and AUD.

Design Participants were randomised to TAU (a single session of brief intervention) or FIT+TAU (TAU with one hospital-based FIT session then eight telephone sessions over 6 months). Pilot outcomes included recruitment rate and retention at day 180. Secondary outcomes included fidelity of FIT delivery, alcohol use, and severity of alcohol dependence.

Results Fifty-four participants (mean age 49; 63% male) were recruited and randomised, 28 to TAU and 26 to FIT+TAU. The retention rate at day 180 was 43%. FIT was delivered adequately by most alcohol nurses. 50% of intervention participants completed FIT sessions 1 and 2. There were no differences in alcohol use or severity of alcohol dependence between treatment groups at day 180.

Conclusion Participants with ARLD and AUD could be recruited to a trial of FIT versus FIT+TAU. However, retention at day 180 was suboptimal. Before conducting a definitive trial of FIT in this patient group, modifications in the intervention and recruitment/retention strategy must be tested.

Trial registration number ISRCTN41353774.

dc.format.extente001267-e001267
dc.format.mediumElectronic
dc.languageen
dc.publisherBMJ
dc.subjectHEALTH ECONOMICS
dc.subjectLIVER CIRRHOSIS
dc.subjectPSYCHOTHERAPY
dc.subjectALCOHOLIC LIVER DISEASE
dc.titleMental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38286518
plymouth.issue1
plymouth.volume11
plymouth.publisher-urlhttp://dx.doi.org/10.1136/bmjgast-2023-001267
plymouth.publication-statusPublished
plymouth.journalBMJ Open Gastroenterology
dc.identifier.doi10.1136/bmjgast-2023-001267
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Research Groups
plymouth.organisational-group|Plymouth|Research Groups|Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group|Plymouth|Research Groups|Centre for Brain, Cognition and Behaviour (CBCB)|Cognition
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|Faculty of Health|School of Psychology
plymouth.organisational-group|Plymouth|Research Groups|Institute of Health and Community
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group|Plymouth|Faculty of Health|Peninsula Medical School
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA04 Psychology, Psychiatry and Neuroscience|UoA04 REF peer reviewers
plymouth.organisational-group|Plymouth|Admin Group - REF
plymouth.organisational-group|Plymouth|Admin Group - REF|REF Admin Group - FoH
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|Research Groups|Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|REF 2028 Researchers by UoA|UoA04 Psychology, Psychiatry and Neuroscience
dc.publisher.placeEngland
dcterms.dateAccepted2024-01-04
dc.date.updated2024-02-06T11:08:11Z
dc.rights.embargodate2024-2-9
dc.identifier.eissn2054-4774
rioxxterms.versionofrecord10.1136/bmjgast-2023-001267


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV